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People who use folate supplements may also consider ensuring adequate vitamin B12 intake, particularly if they are older adults, vegetarians, vegans, or have absorption concerns

Data availability The protein structure from accession codes 1e17 (FOXO4 FHD) was obtained from the PDB at All other data are available from the corresponding author upon reasonable request

Experimental animals A total of 48 Kun-Ming strain male mice were used

Cagrilintide Semaglutide is a combination of two different peptides: semaglutide, which is already known for its powerful effects on weight loss and blood sugar, and cagrilintide, which works a little differently to help control appetite